ⓘ Antibody opsonization


ⓘ Antibody opsonization

Antibody opsonization is the process by which the pathogen is marked for ingestion and eliminated by the phagocytes.

Given the normal inflammatory circumstances, microbial pathogen-associated molecular patterns pamps associated with the endocytic pattern recognition receptors PRRS of phagocytes, which is a mediator mediating neutrophil or macrophage phagocytosis. As well as endocytic PRRS, phagocytes also Express opsonin receptors, such as receptor and the complement receptor CR1 in 1. If the microbe to be covered by opsonising antibodies or C3b of complement, co-stimulation of endocytic PRR and opsonin receptor increases the efficiency of the phagocytic process, improving lysosomal elimination of infectious agents. This mechanism of antibody-mediated increase in phagocytic efficiency is opsonization.

Opsonization involves the binding of the opsonin, e.g., antibody, to an epitope of a pathogen. After opsonin binds to the membrane, phagocytes are attracted to the pathogen. The FAB part of the antibody binds antigen, while the FC portion of antibody binds to FC receptors on phagocytes, promoting phagocytosis. Kernel opsonin receptor complex also generates by-products such as C3b and C4b, which are important components for the effective functioning of the complement system. These components are deposited on the cell surface of the pathogen and aid in its destruction.

Cells can also be destroyed by a process called antibody-dependent cell-mediated cytotoxicity, in which the agent does not need to be phagocytosed to be destroyed. During this process, the agent combines associated with of IgG antibodies through their FAB domain. It allows binding of antibodies from immune effector cells via the FC domain. Antibody-dependent cell-mediated inherent in mediation then triggers the release of lysis products from the bound immune effector cells. The lack of mediation can cause inflammation of the surrounding tissue and damage healthy cells.

  • C1 complex. SP - A opsonizes a number of bacterial and viral pathogens for clearance by lung alveolar macrophages. Antibody opsonization Barret, James 1980
  • target cells with antibodies is sometimes referred to as opsonization The typical ADCC involves activation of NK cells by antibodies An NK cell expresses
  • the binding of the antibody and complement molecules marks the microbe for ingestion by phagocytes in a process called opsonization these phagocytes are
  • Antibody - dependent enhancement ADE occurs when non - neutralizing antiviral proteins facilitate virus entry into host cells, leading to increased infectivity
  • antigen - antibody reaction, the immune complexes can be subject to any of a number of responses, including complement deposition, opsonization phagocytosis
  • immunity. Activation of this system leads to cytolysis, chemotaxis, opsonization immune clearance, and inflammation, as well as the marking of pathogens
  • pathway antibody dependent cell - mediated cytotoxicity or anti - receptor activity. The activation of the complement system results in opsonization the agglutination
  • IgG is a type of antibody Representing approximately 75 of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation
  • Anti - cholesterol Anti - gliadin antibodies Antibody Antibody opsonization Antibody - dependent cell - mediated cytotoxicity Antibody - dependent enhancement Antigen