ⓘ Immunoglobulin heavy chain

                                     

ⓘ Immunoglobulin heavy chain

The immunoglobulin heavy chain is the large polypeptide subunit of an antibody. In human genome, the IgH gene loci are on chromosome 14.

A typical antibody consists of two heavy immunoglobulin chains and two IG light chains iG. There are several different types of heavy chains that define the class or ISATAP antibodies. These heavy chain for different animals. All heavy chains contain a series of immunoglobulin Domains, usually with one variable domain that is important for binding antigen and several constant domains. The production of a viable heavy chain is a key step in B-cell maturation. If the heavy chain is able to communicate with the surrogate light chain and move to the plasma membrane, then developing cells may begin to produce its light chain.

Heavy chains are not always binding to the light chain. Pre-b-cells synthesize heavy chains in the absence of light chain, which can then lead to heavy chain to bind to the heavy chain binding protein.

                                     
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  • Heavy chain may refer to: Immunoglobulin heavy chain a subunit of antibodies Heavy - chain antibody, an antibody composed of heavy chains only Heavy chain
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  • Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of human antibodies or immunoglobulins
  • Heavy chain disease is a form of paraproteinemia and plasma cell dyscrasia that involves the proliferation of cells producing immunoglobulin heavy chains
  • requirements for features of interest. Immunoglobulins include light chains and heavy chains The light chain λ or κ is a protein of 220 amino acids
  • Immunoglobulin heavy constant alpha 1 is a immunoglobulin gene with symbol IGHA1. It encodes a constant C segment of Immunoglobulin A heavy chain Immunoglobulin
  • domains in their heavy chains Naïve mature B cells produce both IgM and IgD, which are the first two heavy chain segments in the immunoglobulin locus. After
  • Immunoglobulin A IgA, also referred to as sIgA in its secretory form is an antibody that plays a crucial role in the immune function of mucous membranes
  • heavy chain is approximately 110 amino acids long and is composed of a single Ig domain. In mammals there are two types of immunoglobulin light chain