ⓘ Histamine H2 receptor

                                     

ⓘ Histamine H2 receptor

H 2 receptors are positively coupled to adenylate cyclase via G s. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. PKA functions to phosphorylate certain proteins, affecting their activity. The drug betazole is an example of a histamine H 2 receptor agonist.