ⓘ Neurofibroma

                                     

ⓘ Neurofibroma

A neurofibroma is a benign nerve-sheath tumor in the peripheral nervous system. In 90% of cases, they are found as stand-alone tumors, while the remainder are found in persons with neurofibromatosis type I, an autosomal-dominant genetically inherited disease. They can result in a range of symptoms from physical disfiguration and pain to cognitive disability.

Neurofibromas arise from nonmyelinating-type Schwann cells that show biallelic inactivation of the NF1 gene that codes for neurofibromin protein. This protein is responsible for regulating the RAS-mediated signaling pathways of cell growth. Unlike schwannoma, another type of tumor arising from Schwann cells, neurofibromas include many additional types of cells and structural elements of the Schwann cells, which makes it difficult to identify and understand all the mechanisms by which they emerge and develop.

                                     
  • A solitary neurofibroma also known as a Solitary nerve sheath tumor, and Sporadic neurofibroma may be 2 to 20mm in diameter, is soft, flaccid, and
  • variously described as Bizarre cutaneous neurofibroma Myxoma of nerve sheath and Pacinian neurofibroma Clinically, neurothekeomas present as a
  • examination. Typically, the lesions are suspected to be schwannomas or neurofibromas clinically with PEN being an incidental finding on histology. PEN is
  • nodules, benign skin tumors called neurofibromas and larger benign tumors of nerves called plexiform neurofibromas scoliosis curvature of the spine
  • List of inclusion bodies that aid in diagnosis of cutaneous conditions Neurofibroma Palisaded encapsulated neuroma James, William Berger, Timothy Elston
  • system. Benign peripheral nerve sheath tumors include schwannomas and neurofibromas A malignant peripheral nerve sheath tumor MPNST is a cancerous peripheral
  • June 4, 1868 January 29, 1957 was a noted Hungarian dermatologist. Neurofibroma multiplex. Budapest, 1893 Dolgozatok a fovarosi bakteriologiai intezetbol
  • of the nervous system rather than the neurons. In NF1 the tumors are neurofibromas tumors of the peripheral nerves while in NF2 and schwannomatosis
  • Aggressive angiomyxoma Myxoid leiomyoma Chondromyxoid fibroma Myxoid neurofibroma Nerve sheath myxoma neurothekeoma Myxolipoma Angiomyofibroblastoma