ⓘ HOGA1

                                     

ⓘ HOGA1

4-Hydroxy-2-oxoglutarate aldolase, mitochondrial also known as dihydrodipicolinate synthase-like is an enzyme that in humans is encoded by the HOGA1 gene. The protein is one of the enzymes involved in metabolism of hydroxyproline to glyoxylate. The enzyme overactivity can form excessive glyoxylate from hydroxyproline. Glyoxylate is catabolised to oxalate, resulting in excess excretion of oxalate in urine, predisposing to oxalate stone, a condition known as primary hyperoxaluria type III.

                                     
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