ⓘ Cubilin

                                     

ⓘ Cubilin

Cubilin CUBN acts as a receptor for intrinsic factor-vitamin B 12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubilin shows a restricted mode of expression according to protein profiling and transcriptomics analyses, and is essentially only present in the kidneys and small intestine. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. A complex of amnionless and cubilin forms the cubam receptor.

                                     
  • vitamin B12. Cubam is essentially composed of amnionless AMN and cubilin Cubilin is essential as a cell receptor recognizing the vitamin B12 - intrinsic
  • proteinuria. It is caused by mutations in the cubilin CUBN or amnionless AMN genes. The protein cubilin binds to intrinsic factor - cobalamin complex
  • ileum. This receptor is composed of two proteins, amnionless AMN and cubilin A defect in either of these protein components can cause this syndrome
  • that in humans is encoded by the AMN gene. A complex of amnionless and cubilin forms the cubam receptor. The protein encoded by this gene is a type I
  • in lysosomes or transcytosis. LRP2 megalin can also form complexes with cubilin those complexes are able to reabsorb several molecules and can be inhibited
  • 2003 Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding Am. J. Physiol. Gastrointest. Liver Physiol
  • Willnow TE, Christensen EI, Moestrup SK October 2001 Megalin - dependent cubilin - mediated endocytosis is a major pathway for the apical uptake of transferrin
  • Navani, Sanjay 2017 - 01 - 04 A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma BMC Cancer
  • the small intestine, and has on its surface specialized receptors called cubilin receptors, that identify the B12 IF complexes and take them up into the