ⓘ Intracellular antibody-mediated degradation

                                     

ⓘ Intracellular antibody-mediated degradation

Intracellular antibody-mediated degradation is a neutralization mechanism of intracellular antibody-mediated immunity whereby an effector protein, TRIM21, directs antibody bound virions to the proteasome where they are degraded. As yet, it has only been observed to act against the adenovirus but is likely to also be effective against other non-enveloped viruses.

                                     
  • foreign substance. The ability of an antibody to communicate with the other components of the immune system is mediated via its Fc region located at the
  • other viruses like dengue virus. ADE in HIV can be complement mediated or Fc receptor mediated Complements in presence of HIV - 1 positive sera have been found
  • also plays an important role in antibody - dependent cell - mediated cytotoxicity ADCC and intracellular antibody - mediated proteolysis, in which it binds
  • receptor - α Interleukin - 8 receptor Interleukin - 9 receptor Intracellular antibody - mediated degradation Intravascular immunity Intrinsic immunity IRGs ISCOM
  • and a coiled coil region. TRIM21 is an intracellular antibody effector in the intracellular antibody - mediated proteolysis pathway. It recognizes Fc domain
  • The antibody binds to microbes with the variable Fab domain, and the Fc domain binds to Fc receptors FcR to induce phagocytosis. Complement - mediated internalisation
  • arthritis. The proteasome is also involved in Intracellular antibody - mediated proteolysis of antibody - bound virions. In this neutralisation pathway
  • IDE, Aβ degradation and Alzheimer s disease. Mice engineered to lack both alleles of the IDE gene exhibit a 50 decrease in Aβ degradation resulting
  • Antibody responses elicited by DNA vaccinations are influenced by multiple variables, including antigen type antigen location i.e. intracellular vs
  • in response to intracellular iron concentration. It imports iron by internalizing the transferrin - iron complex through receptor - mediated endocytosis. The
  • complement - fixing antibodies and leads to cell - mediated immunity. In general, Th1 responses are more effective against intracellular pathogens viruses
  • to destroy microbes, or infected cells by antibody - mediated phagocytosis or antibody - dependent cell - mediated cytotoxicity. Some viruses such as flaviviruses