ⓘ Stratum spinosum

                                     

ⓘ Stratum spinosum

The stratum spinosum is a layer of the epidermis found between the stratum granulosum and stratum basale. Their spiny appearance is due to shrinking of the microfilaments between desmosomes that occurs when stained with H&,E. Keratinization begins in the stratum spinosum. This layer is composed of polyhedral keratinocytes. They have large pale-staining nuclei as they are active in synthesizing fibrilar proteins, known as cytokeratin, which build up within the cells aggregating together forming tonofibrils. The tonofibrils go on to form the desmosomes, which allow for strong connections to form between adjacent keratinocytes. Made of 8-10 layers of living keratinocytes. Gives flexibility and strength.

                                     
  • The stratum basale is a single layer of columnar or cuboidal basal cells. The cells are attached to each other and to the overlying stratum spinosum cells
  • The stratum granulosum or granular layer is a thin layer of cells in the epidermis. Keratinocytes migrating from the underlying stratum spinosum become
  • the stratum basale and stratum spinosum as a unit, although it is occasionally defined as the stratum basale specifically, or the stratum spinosum specifically
  • appearance to their numerous intracellular connections. They make up the stratum spinosum prickly layer of the epidermis and provide a continuous net - like
  • from outer to inner, they are the stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum and stratum basale. The highest concentrations
  • located above the basal cells suprabasal between the stratum corneum and stratum spinosum A very similar non - infectious condition is seen in the autoimmune
  • debilitating disorder Netherton syndrome. Epidermis skin Stratum granulosum Stratum spinosum stratum corneum tryptic enzyme, old name for KLK5 Sadowski T
  • as clear cells when in the stratum basale of the skin, and Langerhans cells appear as clear cells in the stratum spinosum Clear - cell tumors are cancers
  • light touch sensation. The Malpighian layer stratum malpighi is both the stratum basale and stratum spinosum The epidermis is separated from the dermis
  • be exposed after top layers of the dermis stratum corneum, stratum granulosum, stratum spinosum and stratum basale have been removed. This is often uncomfortable
  • sheaths. The outer root sheath corresponds with the stratum mucosum Stratum germinativum and Stratum Spinosum of the epidermis, and resembles it in the rounded
  • layers: Stratum basale basal layer Stratum spinosum prickle layer Stratum granulosum granular layer Stratum lucidum clear layer Stratum corneum