ⓘ Stratum granulosum

                                     

ⓘ Stratum granulosum

The stratum granulosum is a thin layer of cells in the epidermis. Keratinocytes migrating from the underlying stratum spinosum become known as granular cells in this layer. These cells contain keratohyalin granules, which are filled with histidine- and cysteine-rich proteins that appear to bind the keratin filaments together. Therefore, the main function of keratohyalin granules is to bind intermediate keratin filaments together.

The transition between this layer and the stratum corneum, cells secrete lamellar bodies containing lipids and proteins into the extracellular space. This leads to the formation of hydrophobic lipid shell is responsible for the skins barrier properties. Along with this, the cells lose their nuclei and organelles causing the granular cells to become non-viable corneocytes in the stratum corneum.

                                     
  • The stratum spinosum or spinous layer prickle cell layer is a layer of the epidermis found between the stratum granulosum and stratum basale. Their
  • Keratohyalin is a protein structure found in granules in the stratum granulosum of the epidermis, which may be involved in keratinization, and in Hassall s
  • desmoglein I, a cadherin adhesion protein in the desmosomes of the stratum granulosum that facilitates intercellular adhesion between keratinocytes. The
  • Hypergranulosis is an increased thickness of the stratum granulosum Seen in skin diseases with epidermal hyperplasia and orthokeratotic hyperkeratosis
  • cell to journey from the stratum basale to the top of the stratum granulosum and an additional four weeks to cross the stratum corneum. The entire epidermis
  • debilitating disorder Netherton syndrome. Epidermis skin Stratum granulosum Stratum spinosum stratum corneum tryptic enzyme, old name for KLK5 Sadowski T
  • prematurely within individual cells or groups of cells below the stratum granulosum Dyskeratosis congenita is congenital disease characterized by reticular
  • be exposed after top layers of the dermis stratum corneum, stratum granulosum stratum spinosum and stratum basale have been removed. This is often uncomfortable
  • found in the stratum spinosum prickly layer, spinosum layer which lies above the stratum basale basal layer and below the stratum granulosum granular