ⓘ UGT1A9

                                     

ⓘ UGT1A9

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.

                                     
  • UDP - glucuronosyltransferases UGTs S - oxazepam is glucuronidated by UGT 2B15, while R - oxazepam is glucuronidated by UGT 2B7 and UGT1A9 Drug Metab. Dispos. 30
  • encode UGT enzymes include: B3GAT 1 B3GAT2, B3GAT3 UGT 1 A 1 UGT 1 A3, UGT 1 A4, UGT 1 A5, UGT 1 A6, UGT 1 A7, UGT 1 A8, UGT1A9 UGT 1 A10 UGT 2A 1 UGT 2A2, UGT 2A3, UGT 2B4
  • UDP glucuronosyltransferase 1 family, polypeptide A7 is a protein that in humans is encoded by the UGT 1 A7 gene. This gene encodes a UDP - glucuronosyltransferase
  • UDP - glucuronosyltransferase 1 - 1 also known as UGT - 1 A is an enzyme that in humans is encoded by the UGT 1 A 1 gene. UGT - 1 A is a uridine diphosphate glucuronosyltransferase
  • glucuronosyltransferase 2 family, polypeptide B 1 also known as UGT 2B 1 is an enzyme that in humans is encoded by the UGT 2B 1 gene. The olfactory neuroepithelium
  • UDP - glucuronosyltransferase 1 - 8 is an enzyme that in humans is encoded by the UGT 1 A8 gene. This gene encodes a UDP - glucuronosyltransferase, an enzyme of
  • UDP - glucuronosyltransferase 1 - 10 is an enzyme that in humans is encoded by the UGT 1 A10 gene. This gene encodes a UDP - glucuronosyltransferase, an enzyme
  • UDP - glucuronosyltransferase 1 - 6 is an enzyme that in humans is encoded by the UGT 1 A6 gene. UDP - glucuronosyltransferase 1 - 6 is a UDP - glucuronosyltransferase
  • UGT 2B7 UDP - Glucuronosyltransferase - 2B7 is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal
  • 2 family, polypeptide B4, also known as UGT 2B4, is an enzyme that in humans is encoded by the UGT 2B4 gene. UGT 2B4 is mainly involved in the glucuronidation
  • UDP glucuronosyltransferase 1 family, polypeptide A cluster, also known as UGT 1 A is a human gene. This RefSeq represents a complex locus that encodes