ⓘ Cation-dependent mannose-6-phosphate receptor

                                     

ⓘ Cation-dependent mannose-6-phosphate receptor

In the fields of biochemistry and cell biology, the cation-dependent mannose-6-phosphate receptor also known as the 46 kDa mannose 6-phosphate receptor is a protein that in humans is encoded by the M6PR gene.

The CD-MPR is one of two transmembrane proteins that bind mannose-6-phosphate M6P tags on acid hydrolase precursors in the Golgi apparatus, destined for transport to lysosomes. Homologs of the CD-MPR in all eukaryotes.

                                     
  • mannose 6 - phosphate receptors MPRs are transmembrane glycoproteins that target enzymes to lysosomes in vertebrates. Mannose 6 - phosphate receptors bind
  • Mannose - 6 - phosphate receptor binding protein 1 M 6 PRBP1 is a protein which in humans is encoded by the M 6 PRBP1 gene. Its gene product, as well as the
  • Ghosh P, Kornfeld S May 2002 Interaction of the cation - dependent mannose 6 - phosphate receptor with GGA proteins The Journal of Biological Chemistry
  • an amino - terminal VHS domain which mediates sorting of the mannose 6 - phosphate receptors at the trans - Golgi network. They also contain a carboxy - terminal
  • mannose - 6 - phosphate is accomplished by two proteins: CI - MPR cation - independent mannose - 6 - phosphate receptor and CD - MPR cation - dependent mannose - 6 - phosphate
  • death receptors and chemotherapy drugs. The main mechanism of trafficking L - SMase to the lysosome is through the mannose 6 - phosphate receptor mediated
  • 5 - trisphosphate receptor Ca2 channel family 1.A.4 Transient receptor potential Ca2 channel family 1.A.5 Polycystin cation channel family 1.A. 6 Epithelial
  • this interaction promoted retrograde transport of the cation - independent mannose 6 - phosphate receptor to the Trans - Golgi Network in a Rac - independent manner
  • is an enzyme that facilitates phosphorylation of glucose to glucose - 6 - phosphate Glucokinase occurs in cells in the liver and pancreas of humans and
  • an amino - terminal VHS domain which mediates sorting of the mannose 6 - phosphate receptors at the trans - Golgi network. They also contain a carboxy - terminal