ⓘ CYP2A6

                                     

ⓘ CYP2A6

Cytochrome P450 2A6 is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.

The CYP2A6 gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to CYP2A3, however, it has been renamed CYP2A6.

                                     
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  • Cytochrome P450 2 D 6 CYP 2 D 6 is an enzyme that in humans is encoded by the CYP 2 D 6 gene. CYP 2 D 6 is primarily expressed in the liver. It is also highly expressed
  • a cluster including other CYP2 family members such as CYP2A6 CYP 2 A13, CYP 2 B 6 and CYP 2 F1. CYP 2 S1 is highly expressed in epithelial tissues of the respiratory
  • in Coumarin 7 - Hydroxylation: Sequence of the Human CYP 2 A Gnes and Identification of Variant CYP2A6 Alleles Am. J. Hum. Genet. 57 3 651 60. PMC 1801261
  • in coumarin 7 - hydroxylation: sequence of the human CYP 2 A genes and identification of variant CYP2A6 alleles Am J Hum Genet. 57 3 651 60. PMC 1801261
  • Cytochrome P450 2 C9 abbreviated CYP 2 C9 is an enzyme that in humans is encoded by the CYP 2 C9 gene. CYP 2 C9 is an important cytochrome P450 enzyme with
  • Cytochrome P450 2 C19 abbreviated CYP 2 C19 is an enzyme. This protein, a member of the cytochrome P450 mixed - function oxidase system, is involved in the
  • metabolism of xenobiotics in the body. In humans, the CYP 1A 2 enzyme is encoded by the CYP 1A 2 gene. CYP 1A 2 is a member of the cytochrome P450 superfamily of
  • has also been shown to inhibit CYP2A6 and other CYPs Watercress is also a known inhibitor of the cytochrome P450 CYP 2 E1, which may result in altered
  • is a potential carcinogen It is metabolized in the liver by the enzyme CYP2A6 Bulay O, Mirvish SS September 1979 Carcinogenesis in rat esophagus
  • Cytochrome P450 2 J 2 CYP 2 J 2 is a protein that in humans is encoded by the CYP 2 J 2 gene. CYP 2 J 2 is a member of the cytochrome P450 superfamily of enzymes