ⓘ Harmane

                                     

ⓘ Harmane

Harmane is a potent reversible inhibitor of monoamine oxidase A RIMA and acts as a moderate affinity inverse agonist at the benzodiazepine site of the GABA-A receptor. Harmane has been suggested as a potential candidate or component thereof for the endogeneous ligand of imidazoline receptor, although the evidence is limited and equivocal.

In rats, harmane damage to several dopaminergic dendritic arbors in high enough doses. Blood levels of harmane and similar beta-carbolines associated with essential tremor and Parkinsons disease.