ⓘ Placental alpha microglobulin-1 (PAMG-1)

                                     

ⓘ Placental alpha microglobulin-1 (PAMG-1)

Placental alpha microglobulin-1 is a human protein that was first isolated in 1975 from amniotic fluid. PAMG-1 is an important biomarker for the detection of premature rupture of fetal membrane The high concentration of PAMG-1 in amniotic fluid means it can be used to detect if this fluid is present in the cervico-vaginal discharge of pregnant women, the presence of PAMG-1 in the discharge suggests that amniotic fluid is present, and therefore suggests that PROM has occurred. PAMG-1 was originally referred to as specific alpha-1 globulin of placenta.

PAMG-1 is present in the blood and amniotic fluid and cervico-vaginal discharge of pregnant women. Concentration of PAMG-1 in amniotic fluid of pregnant women 2.000–25.000 ng / ml, however, is several thousand times greater than their background cervico-vaginal secretions when the fetal membranes are intact 0.05–0.2 ng / ml. It was discovered in amniotic fluid in significantly higher concentrations during all three trimesters of pregnancy.

                                     
  • about 5 of all cases of PROM. Placental alpha microglobulin - 1 PAMG - 1 IGFBP 1 Insulin - like growth factor binding protein - 1 Norwitz, Errol R. Arulkumaran
  • Evaluation of a novel placental alpha microglobulin - 1 PAMG - 1 test to predict spontaneous preterm delivery. J Perinat Med. 2013 Dec 13: 1 - 5. Nikolova T, Bayev