ⓘ Acetyl-CoA carboxylase

                                     

ⓘ Acetyl-CoA carboxylase

Acetyl-CoA carboxylase is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase and carboxyltransferase. ACC is a multi-subunit enzyme in most prokaryotes and in the chloroplasts of most plants and algae, whereas it is a large, multi-domain enzyme in the endoplasmic reticulum of most eukaryotes. The most important function of ACC is to provide the malonyl-CoA substrate for the biosynthesis of fatty acids. The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification. The human genome contains the genes for two different ACCs - ACACA and ACACB.

                                     
  • Acetyl - CoA acetyl coenzyme A is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism. Its main function
  • ligase ADP - forming This enzyme is also called biotin carboxylase component of acetyl CoA carboxylase This enzyme participates in fatty acid biosynthesis
  • Acetyl - CoA carboxylase 1 also known as ACC - alpha or ACCa is an enzyme that in humans is encoded by the ACACA gene. Acetyl - CoA carboxylase ACC is a complex
  • Acetyl - CoA carboxylase 2 also known as ACC - beta or ACC2 is an enzyme that in humans is encoded by the ACACB gene. Acetyl - CoA carboxylase ACC is a complex
  • Methylcrotonyl CoA carboxylase MCC 3 - methylcrotonyl CoA carboxylase methylcrotonoyl - CoA carboxylase is a biotin - requiring enzyme located in the mitochondria
  • synthesis. Malonyl - CoA is formed by carboxylating acetyl - CoA using the enzyme acetyl - CoA carboxylase One molecule of acetyl - CoA joins with a molecule
  • In this pathway CO 2 is fixed i.e. incorporated by the action of two enzymes, acetyl - CoA carboxylase and propionyl - CoA carboxylase These enzymes generate
  • into acetyl - CoA and carbon dioxide. It is involved in fatty acid biosynthesis. To some degree, it reverses the action of Acetyl - CoA carboxylase MCD presents
  • molecule for oxidation. Acetyl - CoA carboxylase catalyzes the production of malonyl - CoA from acetyl - CoA Malonyl - CoA reduces the activity of carnitine
  • Propionyl - CoA carboxylase PCC catalyses the carboxylation reaction of propionyl CoA in the mitochondrial matrix. The enzyme is biotin - dependent. The