ⓘ CYP2C9*3

                                     

ⓘ CYP2C9*3

Cytochrome P450 2C9, a member of the CYP2C enzyme subfamily, ranks amongst the most important drug metabolizing enzymes in humans.

Human CYP2C9 has been shown on exhibit genetic polymorphism. In addition to the wild-type protein CYP2C9*1 at least, 32 single nucleotide polymorphisms SNPS have been reported in the coding region of the gene CYP2C9, producing the option allozyme. Cyp2c9*3 is one of them. Cyp2c9*3 reflects an Ile359-LEU I359L change in amino acid sequence and the decrease in catalytic activity compared with the wild type CYP2C9*1.