ⓘ FOXD3

                                     

ⓘ FOXD3

This gene belongs to the forkhead protein family of transcription factors which is characterized by a DNA-binding forkhead domain. FoxD3 functions as a transcriptional repressor and contains the C-terminal engrailed homology-1 motif eh1, which provides an interactive surface with a transcriptional co-repressor Grg4 Groucho-related gene-4.

Several studies suggest the participation of Foxd3 in the transition from naive to primed pluripotent stem cells during embryonic development. Earlier, Foxd3 was shown necessary in the maintenance of pluripotency in embryonic stem cells of mice. Recent results further showed that Foxd3 is necessary as a repressor in the transition from Esc to epiblast-like cells EpiLC. The study suggested that Foxd3 is associated with the inactivation of important naive pluripotency genes and modification of chromatin structure through recruitment of histone demethylases and reduce the number of activating factors. The other proposed mechanism, on the other hand, argued that Foxd3 begins with the removal and induction into the "primed" pluripotent state through the recruitment of Brg1 and nucleosomes paramodular, and then acts as a repressor maximum activation of these amplifiers, attracting discontinueties, suggesting a complex intermediary function in which the amplifiers are primed for certain future controlled by time, rather than the direct expression. While there is no ambiguity that Foxd3 plays an important role in regulating the transition from naive to primed pluripotency state, these two models suggest a different process. Attempts to reconcile the findings of two studies it was suggested that the functions of Foxd3, as all of the above.

                                     
  • Forkhead box protein D4 is a protein that in humans is encoded by the FOXD 4 gene. GRCh38: Ensembl release 89: ENSG00000170122 - Ensembl, May 2017 GRCm38:
  • FOXA 3 See also Hepatocyte nuclear factors FOXB1, FOXB2 FOXC1 assoc. with Glaucoma FOXC2 varicose veins FOXD 1, FOXD 2, FOXD3 vitiligo FOXD 4, FOXD 5
  • Forkhead box D1 is a protein that in humans is encoded by the FOXD 1 gene. Forkhead d1 is a kidney expressed transcription factor maps at the chromosome
  • cell types and has to be removed only when cell differentiation begins. FoxD3 has been associated as a repressor of both B - cell and melanocytic cell differentiation
  • sufficient for the expression of Slug, Snail, and FoxD3 Furthermore, Pax 3 is essential for FoxD3 expression in mouse embryos. Following the expression
  • differentiation and migration of neural crest cells along with other genes e.g. FOXD3 SOX9 and SOX10, BMPs in embryonic life. Mutations in this gene may be
  • neurons. Other cofactors have been identified, such as SP1, OCT6, NMI, FOXD3 and SOX2 The interaction between SOX10 and NMI seems to be coexpressed in
  • in chimpanzee chromosomes 2A and 2B. Additional linked copies of the PGML FOXD CBWD genes exist elsewhere in the human genome, particularly near the p end
  • in the lack of activation of the specific neural crest genes Snail2 and Foxd3 which didn t allow further development or emigration of neural crest. Using
  • PMID 11821690. Freyaldenhoven BS, Fried C, Wielckens K July 2002 FOXD 4a and FOXD 4b, two new winged helix transcription factors, are expressed in human
  • Bronner, M.E. 2012 Dynamic and differential regulation of stem cell factor FoxD3 in the neural crest is encrypted in the genome PLoS. Genetics e1003142.