ⓘ Recombination signal sequences

                                     

ⓘ Recombination signal sequences

Recombination signal sequences are conserved sequences of noncoding DNA that are recognized by the RAG1/RAG2 enzyme complex during VJ recombination in immature B cells and T cells. Recombination signal sequences guide the enzyme complex to the V, D, and J gene segments that will undergo recombination during the formation of the heavy and light-chain variable regions in T-cell receptors and immunoglobulin molecules.

                                     
  • PMID 26548953. Kapitonov VV, Jurka J June 2005 RAG1 core and V D J recombination signal sequences were derived from Transib transposons PLoS Biology. 3 6
  • To maintain the specificity of recombination V D J recombinase recognizes and binds to Recombination Signal Sequences RSSs flanking the variable V
  • Uptake signal sequence USS are short DNA sequences preferentially taken up by competent bacteria belonging to the Pasteurellaceae family e.g., Haemophilus
  • Homologous recombination is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of double - stranded
  • Illegitimate recombination or nonhomologous recombination is the process by which two unrelated double stranded segments of DNA are joined. This insertion
  • During V D J recombination the RAG complex made up of RAG - 1 and RAG - 2 complexed with HMG1 or HMG2 binds to two recombination signal sequences RSSs the
  • sites, known as loxP sequences contain specific binding sites for Cre that surround a directional core sequence where recombination can occur. When cells
  • The Recombination Hypothesis is the 100th episode of the American sitcom The Big Bang Theory and the 13th episode of the series fifth season. It premiered
  • belcheri Chinese lancelet The TIRs are structurally similar to Recombination signal sequences RSS The heptamer bears the consensus CACWRTG, while the nonamer
  • A Chi site or Chi sequence is a short stretch of DNA in the genome of a bacterium near which homologous recombination is more likely to occur than on
  • activity also requires RAG - 2. The RAG - 1 2 complex recognizes recombination signal sequences RSSs that flank the V, D and J regions in the genes that encode
  • statisticians in the UK Russell - Silver syndrome, a form of dwarfism Recombination signal sequences genes used to generate antibodies and T - cell receptors in immunology