ⓘ Zona reticularis

                                     

ⓘ Zona reticularis

The zona reticularis is the innermost layer of the adrenal cortex, lying deep to the zona fasciculata and superficial to the adrenal medulla. The cells are arranged cords that project in different directions giving a net-like appearance.

Cells in the mesh area to produce precursor androgens including dehydroepiandrosterone DHEA and Androstenedione from cholesterol. DHEA is further converted to DHEA-sulfate via a sulfotransferase, SULT2A1. These precursors are not further converted in the adrenal cortex, if not 17бета hydroxysteroid dehydrogenase. Instead, they get into the blood stream and in the testes and ovaries to produce testosterone and estrogens respectively.

ACTH partially regulates the secretion of adrenal androgens, as well as CRH.

In humans, the mesh layer contains 17-alpha-hydroxylase, in this hydroxylates pregnenolone, which is then converted to cortisol mixed-function oxidase. In rodents, insufficient 17альфа-hydroxylase results in the synthesis of cortisol, corticosterone, but not in person.

                                     
  • The zona fasciculata constitutes the middle and also the widest zone of the adrenal cortex, sitting directly beneath the zona glomerulosa. Constituent
  • dehydroepiandrosterone DHEA and dehydroepiandrosterone sulfate DHEA - S from the zona reticularis of the adrenal glands with age. Levels of adrenal androgens start to
  • capacity of the zona fasciculata increases during illness in infants. Zona reticularis The inner most cortical layer, the zona reticularis produces androgens
  • cortex itself is divided into three zones: the zona glomerulosa, the zona fasciculata and the zona reticularis The adrenal cortex produces three main types
  • pyknotic nuclei arrows 400x Pyknotic nuclei are often found in the zona reticularis of the adrenal gland. They are also found in the keratinocytes of the
  • 407.071.140.950 - - - zona fasciculata MeSH A06.407.071.140.960 - - - zona glomerulosa MeSH A06.407.071.140.970 - - - zona reticularis MeSH A06.407.071.265
  • result of the development of a new zone of the adrenal cortex, the zona reticularis Adrenarche is a process related to puberty, but distinct from
  • expressed in many tissues and cell types, including the zona reticularis of the adrenal cortex and zona fasciculata as well as gonadal tissues. This gene encodes
  • comprises three concentric zones including the zona Glomerulosa zG zona Fasciculata zF and zona Reticularis zR that under normal conditions respond
  • which relays the signal to the adrenal cortex. Here, the zona fasciculata and zona reticularis in response to ACTH, secrete glucocorticoids, in particular