ⓘ JWH-051

                                     

ⓘ JWH-051

JWH-051 is an analgesic drug which is a cannabinoid agonist. Its chemical structure is closely related to that of the potent cannabinoid agonist HU-210, with the only difference being the removal of the hydroxyl group at position 1 of the aromatic ring. It was discovered and named after John W. Huffman.

Was JWH-051 retains high affinity for SV 1 receptor, but is a much stronger agonist for CB 2, with the value Ki 14нм in CB 2 vs 19 nm for 1 KB. He was one of the first, CB 2 -selective ligands developed, although its selectivity for CB 2 modest compared to newer compounds such as Hu-308.

It has similar effects to other cannabinoid agonists, such as sedation and analgesia, but with a relatively strong antiinflammatory effect due to its strong activity on KB 2.