ⓘ FPGT

                                     

ⓘ FPGT

Fucose-1-phosphate guanylyltransferase is an enzyme that in humans is encoded by the FPGT gene.

L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many functional roles of these macromolecules, such as cell–cell recognition. In the fucosyl donor for these fucosylated oligosaccharides, GDP-beta-L-fucose. There are two alternative pathways of biosynthesis of GDP-fucose, a main pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene, is involved in the alternative pathway, which is present in certain mammalian tissues such as the liver and kidneys, and it seems that acts as the way of salvation, to re-use L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTR fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose.

                                     
  • FBXO2: F - box protein 2 FNBP1L encoding protein Formin - binding protein 1 - like FPGT Fucose - 1 - phosphate guanylyltransferase FUBP1 1p31 GALE: UDP - galactose - 4 - epimerase
  • HGNC: 26264 Q8IWF2 5875 FOXS1 HGNC: 3735 O43638 5876 FPGS HGNC: 3824 Q05932 5877 FPGT HGNC: 3825 O14772 5878 FPR1 HGNC: 3826 P21462 5879 FPR2 HGNC: 3827 P25090 5880