ⓘ ULBP3

                                     

ⓘ ULBP3

UL16 binding protein 3 is a cell surface glycoprotein encoded by ULBP3 gene located on the chromosome 6. ULBP3 is related to MHC class I molecules, but its gene maps outside the MHC locus. The domain structure of ULBP3 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP3 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor. It functions as a stress-induced ligand for NKG2D receptor.

                                     
  • UL16 binding protein 1 ULBP 1 is a cell surface glycoprotein encoded by ULBP 1 gene located on the chromosome 6. ULBP 1 is related to MHC class I molecules
  • UL16 binding protein 2 ULBP 2 is a cell surface glycoprotein encoded by ULBP 2 gene located on the chromosome 6. ULBP 2 is related to MHC class I molecules
  • families of MHC class I - related proteins: MICs MICA, MICB and ULBPs ULBP 1, ULBP 2, ULBP3 ULBP 4, RAET1G, RAET1L Other receptors able to bind induced - self
  • human RAET1 ULBP genes, six encode functional proteins: RAET1E ULBP 4, RAET1G ULBP 5, RAET1H ULBP 2, RAET1 ULBP 1, RAET1L ULBP 6, RAET1N ULBP3 In mice, proteins
  • infection, but HCMV alters its function. HCMV - encoded UL16 glycoprotein retains ULBP 6 inside the cells, preventing it from reaching the cell surface and being
  • revealed by the cocrystal structure of NKG2D and its class I MHC - like ligand ULBP3 Immunity. 15 6 1039 49. doi: 10.1016 S1074 - 7613 01 00241 - 2. PMID 11754823
  • L Lawrence, William A Rein - Weston, Annie Cosman, David 2003 - 05 - 23 ULBP 4 is a novel ligand for human NKG2D Biochemical and Biophysical Research
  • I homologues MICA MHC class I polypeptide - related sequence A MICB and ULBP UL - 16 binding protein in human. MICA and MICB are expressed on the surface
  • Easom, Nicholas Young, Neil T. Trowsdale, John 2004 - 07 - 15 Two Human ULBP RAET1 Molecules with Transmembrane Regions Are Ligands for NKG2D The Journal