ⓘ PCDHA3

                                     

ⓘ PCDHA3

Protocadherin alpha-3 is a protein that in humans is encoded by the PCDHA3 gene.

This gene is a member of the cluster of protocadherin alpha gene, one of three related gene clusters, tandemly linked on chromosome 5, which demonstrate an unusual genomic organization similar to B-cell and T-cell receptor gene clusters.

The alpha gene cluster is composed of the 15 cadherin superfamily genes related to KNP mouse genes and consists of 13 very similar and 2 more distantly related coding sequences. The tandem array of 15 n-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are common to all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain.

These neural cadherin-cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and operation of specific intercellular connections in the brain. Alternative splicing has been observed and proposed additional options, but their full-length nature has yet to be determined.

                                     
  • PCDH19 PCDH20 PCDHA 1 PCDHA 2 PCDHA3 PCDHA 4 PCDHA 5 PCDHA 6 PCDHA 7 PCDHA 8 PCDHA 9 PCDHA 10 PCDHA 11 PCDHA 12 PCDHA 13 PCDHAC1 PCDHAC2 PCDHB1 PCDHB2 PCDHB 3 PCDHB4 PCDHB5
  • Protocadherin alpha - 2 is a protein that in humans is encoded by the PCDHA 2 gene. This gene is a member of the protocadherin alpha gene cluster, one of
  • Protocadherin alpha - 12 is a protein that in humans is encoded by the PCDHA 12 gene. This gene is a member of the protocadherin alpha gene cluster, one
  • Protocadherin alpha - 9 is a protein that in humans is encoded by the PCDHA 9 gene. This gene is a member of the protocadherin alpha gene cluster, one of
  • PCDH19 PCDH20 PCDHA 1 PCDHA 2 PCDHA3 PCDHA 4 PCDHA 5 PCDHA 6 PCDHA 7 PCDHA 8 PCDHA 9 PCDHA 10 PCDHA 11 PCDHA 12 PCDHA 13 PCDHAC1 PCDHAC2 PCDHB1 PCDHB2 PCDHB 3 PCDHB4 PCDHB5
  • Protocadherin alpha - 5 is a protein that in humans is encoded by the PCDHA 5 gene. This gene is a member of the protocadherin alpha gene cluster, one of
  • Protocadherin alpha - 4 is a protein that in humans is encoded by the PCDHA 4 gene. This gene is a member of the protocadherin alpha gene cluster, one of
  • Protocadherin alpha - 6 is a protein that in humans is encoded by the PCDHA 6 gene. This gene is a member of the protocadherin alpha gene cluster, one of