ⓘ PCDHGA11

                                     

ⓘ PCDHGA11

Protocadherin gamma-A11 is a protein that in humans is encoded by the PCDHGA11 gene.

This gene is a member of the protocadherin gamma gene cluster one of three related clusters tandemly linked on chromosome 5. These gene clusters have an immunoglobulin-like organization, suggesting that a new mechanism may be involved in their regulation and expression.

The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily a contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are accompanied by a constant region, containing 3 exons common to all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. Constant region exons encode the common cytoplasmic region.

These neural cadherin-like cell adhesion proteins most likely play an important role in the establishment and operation of specific intercellular connections in the brain. Alternative splicing has been described for the gamma cluster genes.

                                     
  • PCDHB 11 PCDHB12 PCDHB13 PCDHB14 PCDHB15 PCDHB16 PCDHB17 PCDHB18 PCDHGA 1 PCDHGA 2 PCDHGA 3 PCDHGA 4 PCDHGA 5 PCDHGA 6 PCDHGA 7 PCDHGA 8 PCDHGA 9 PCDHGA 10 PCDHGA11 PCDHGA12
  • Protocadherin gamma - A12 is a protein that in humans is encoded by the PCDHGA 12 gene. This gene is a member of the protocadherin gamma gene cluster, one