ⓘ RGS17

                                     

ⓘ RGS17

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein GAP, increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Along with RGS4, RGS9 and RGS14, RGS17 plays an important role in termination of signalling by mu opioid receptors and development of tolerance to opioid analgesic drugs.

                                     
  • interest as the most important RGS protein involved in terminating signalling by the mu opioid receptor although RGS 4 and RGS17 are also involved and is
  • also of interest as one of the three main RGS proteins along with RGS 9 and RGS17 involved in terminating signalling by the mu opioid receptor, and may
  • GRK6, GRK7 RGS 1, RGS 2, RGS 3, RGS 4, RGS 5, RGS 6, RGS 7, RGS 8, RGS 9, RGS 10, RGS 11, RGS 12, RGS 13, RGS 14, RGS 16, RGS17 RGS 18, RGS 19, RGS 20, RGS 21 SNX13 GTP - binding
  • of G - protein signaling 16 is a protein that in humans is encoded by the RGS 16 gene. The protein encoded by this gene belongs to the regulator of G protein
  • encoded by the RGS 11 gene. The protein encoded by this gene belongs to the RGS regulator of G protein signaling family. Members of the RGS family act as
  • 13 is a protein that in humans is encoded by the RGS 13 gene. RGS 13 is a member of R4 subfamily of RGS Regulators of G Protein Signaling proteins which
  • 5 is a protein that in humans is encoded by the RGS 5 gene. The regulator of G protein signaling RGS proteins are signal transduction molecules that
  • encoded by the RGS 8 gene. This gene is a member of the regulator of G protein signaling RGS family and encodes a protein with a single RGS domain. Regulator
  • that in humans is encoded by the RGS 12 gene. This gene encodes a member of the regulator of G protein signaling RGS gene family. The encoded protein
  • encoded by the RGS 2 gene. It is part of a larger family of RGS proteins that control signalling through G - protein coupled receptors GPCR RGS 2 is thought
  • Royal Grammar School, Newcastle upon Tyne, usually abbreviated as RGS is a selective British independent school for pupils aged between 7 and 18 years
  • The Royal Geographical Society RGS is the United Kingdom s learned society and professional body for geography, founded in 1830 for the advancement