ⓘ KIAA1279

                                     

ⓘ KIAA1279

KIF1-binding protein, also known as Kinesin binding protein, is a protein that in humans is encoded by the KIAA1279 gene. The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator. Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate,ref name = "Brouwers_2017" />, and any defect in their interaction leads to delay in chromosomal alignment during mitosis. Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis, and hence it can be therapeutically used to control Kif15 upregulated cancer cells.

                                     
  • Goldberg Shprintzen is a condition associated with mutations in KIAA1279 gene which encodes KIF - binding protein KBP a protein that may interact with
  • produced by alternative splicing. RGR - opsin has been shown to interact with KIAA1279 GRCh38: Ensembl release 89: ENSG00000148604 - Ensembl, May 2017 GRCm38:
  • both D and L amino acids. Dipeptidase 1 has been shown to interact with KIAA1279 DPEP1 has been found to be highly expressed in colon tumor cells compared
  • unidentified human genes. III. The coding sequences of 40 new genes KIAA 0081 - KIAA 0120 deduced by analysis of cDNA clones from human cell line KG - 1
  • conserved regulatory domain The EMBO Journal. 16 6 1279 90. doi: 10.1093 emboj 16.6. 1279 PMC 1169726. PMID 9135144. Wu Z, Wu J, Jacinto E, Karin