ⓘ MAPK10

                                     

ⓘ MAPK10

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases JNKs. Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase 4 MKK4. Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

                                     
  • kinase 15, also known as MAPK 15, ERK7, or ERK8, is an enzyme that in humans is encoded by the MAPK 15 gene. Evolutionarily, MAPK 15 is conserved in a number
  • Mitogen - activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK 4 gene. Mitogen - activated protein kinase 4 is a member of the mitogen - activated
  • Mitogen - activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK 6 gene. The protein encoded by this gene is a member of the Ser Thr protein
  • Mitogen - activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK 11 gene. The protein encoded by this gene is a member of the MAP kinase family
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  • protein kinase 13 MAPK 13 also known as stress - activated protein kinase 4 SAPK4 is an enzyme that in humans is encoded by the MAPK 13 gene. The protein
  • protein kinase 3 SAPK3 is an enzyme that in humans is encoded by the MAPK 12 gene. Activation of members of the mitogen - activated protein kinase family
  • determined. MAPK 8IP3 has been shown to interact with ASK1, C - Raf, PTK2, MAPK10 Mitogen - activated protein kinase 9, MAPK 8, MAP2K1, KLC2, MAP2K7, KLC1, MAPK 8IP2
  • The MAPK ERK pathway also known as the Ras - Raf - MEK - ERK pathway is a chain of proteins in the cell that communicates a signal from a receptor on the surface
  • Mitogen - activated protein kinase 3, also known as p44 MAPK and ERK1, is an enzyme that in humans is encoded by the MAPK 3 gene. The protein encoded by this gene is