ⓘ Autoimmune neutropenia


ⓘ Autoimmune neutropenia

Autoimmune neutropenia is a form of neutropenia which is most common in infants and young children where the body identifies the neutrophils as enemies and makes antibody to destroy them.

Primary autoimmune neutropenia, also known as autoimmune neutropenia, is an autoimmune disease, first published in 1975 that primarily occurs in infancy. In autoimmune neutropenia, the immune system produces autoantibodies directed against the neutrophilic protein antigens in white blood cells of the granulocytic neutrophils granulocytes segmented neutrophils, segments, polysegmented neutrophils or polys. These antibodies, IgG antibodies destroy granulocytic neutrophils. Therefore, patients with autoimmune neutropenia have low granulocytic neutrophils causing a neutropenia state. Neutropenia causes an increased risk of infection from the body, the body is usually easy to fight.

Primary autoimmune neutropenia is reportedly already in the second month of life although most cases are diagnosed in children aged 5 to 15 months of age. Girls have a slightly higher risk of developing not more than boys, and Caucasian background. In neutropenia detected at birth or shortly after birth, the diagnosis ALLO-immune neutropenia from maternal white blood cells antibodies passively transferred to the infant is more likely.

Newborns neutropenia is defined by absolute neutrophils less than 1000 / µl. After the first year of life neutropenia is defined by absolute values less than 1500 / µl. Neutropenia can be primary, in which he only saw the abnormality of blood. In secondary neutropenia, there are other basic conditions, including other autoimmune diseases, infections and cancer. Neutropenia is chronic when it persists for more than 6 months.

  • subtypes of neutropenia exist which are rarer and chronic, including acquired idiopathic neutropenia cyclic neutropenia autoimmune neutropenia and congenital
  • platelets, general body health Isolated neutropenia in infants can occur in viral infections, autoimmune neutropenia of infancy, bone marrow suppression from
  • be intermittent or chronic. These include: Autoimmune hemolytic anemia, Autoimmune neutropenia Autoimmune thrombocytopenia. Other signs can affect organ
  • This list of autoimmune diseases is categorized by organ and tissue type to help locate diseases that may be similar. Overview of the qualifiers for the
  • autoimmunity. The autoimmune phenotype can present in childhood or adulthood and primarily includes autoimmune hemolytic anemia, ITP, and neutropenia Some patients
  • body. Leukopenia - a deficiency of white blood cells, or leukocytes Neutropenia - a type of leukopenia, with a specific deficiency in neutrophils Thrombocytopenia
  • neutrophils stimulates an autoimmune response which leads to arthritis. The loss and destruction of neutrophils leading to neutropenia is therefore, inflammation - driven
  • spotted fever Blood and immune causes: chronic neutropenia and myeloproliferative disorders. Autoimmune diseases and vasculitis: systemic lupus erythematosus
  • measure and in patients suffering from an overactive immune system, as in autoimmune diseases. Some people are born with intrinsic defects in their immune
  • hemolytic anemia direct Coombs test is positive Autoimmune hemolytic anemia Warm antibody autoimmune hemolytic anemia Idiopathic Systemic lupus erythematosus