ⓘ DDX46

                                     

ⓘ DDX46

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp DEAD, are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex, it plays an important role in pre-mRNA splicing.

                                     
  • as a microtubule - binding protein. SF3A2 has been shown to interact with DDX46 GRCh38: Ensembl release 89: ENSG00000104897 - Ensembl, May 2017 Human
  • RIG - I - like receptor dsRNA helicase enzyme that is encoded in humans by the DDX 58 gene. RIG - I is part of the RIG - I - like receptor family, which also includes
  • CHD6, CHD7, CHD8, CHD9 DEAD box DEAD DEAH box helicase: DDX 3X, DDX 5, DDX 6, DDX 10, DDX 11, DDX 12, DDX 58, DHX8, DHX9, DHX37, DHX40, DHX58 ASCC3, BLM, BRIP1
  • helicase Ddx 19 in its ADP - bound state reveals the molecular basis for the interaction between the two proteins. A conserved residue of Ddx 19 is shown
  • Eukaryotic initiation factor 4A - I also known as eIF4A1 or DDX 2A is a 46 kDa cytosolic protein that in humans is encoded by the EIF4A1 gene, which, in
  • polypeptide 36 Abdelhaleem M, Maltais L, Wain H June 2003 The human DDX and DHX gene families of putative RNA helicases Genomics. 81 6 618 22
  • chromosome 1. DHX9 has been shown to interact with: AKAP8L, BRCA1, DDX 17 p72 DDX 5 p68 KHDRBS1, MIZF, NXF1, PRMT1, RELA, and SMN1. GRCh38: Ensembl
  • re - localisation to SGs. Abdelhaleem M, Maltais L, Wain H June 2003 The human DDX and DHX gene families of putative RNA helicases Genomics. 81 6 618 22
  • found in a single copy per protein. AKAP1 ANKHD1 ANKRD17 ASCC1 BICC1 DDX 43 DDX 53 DPPA5 FMR1 FUBP1 FUBP3 FXR1 FXR2 GLD1 HDLBP HNRPK IGF2BP1
  • infected cells. Several DNA sensors, such as DAI, RNA polymerase III, IFI16, DDX 41 and cGAS, can detect foreign nucleic acids. After recognizing viral DNA
  • subunit 40S and eIF3. Eukaryotic translation DExD H box proteins Ded1 DDX 3 GRCh38: Ensembl release 89: ENSG00000067248 - Ensembl, May 2017 GRCm38: