ⓘ SEC62

                                     

ⓘ SEC62

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum ER membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

                                     
  • encoded by this gene and SEC62 protein are found to be associated with ribosome - free SEC 61 complex. It is speculated that Sec 61 - Sec62 - Sec 63 may perform post - translational
  • melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec 61 and Sec 63 constituents of the general protein secretory
  • PMID 10601334. Meyer HA, Grau H, Kraft R, et al. 2000 Mammalian Sec 61 is associated with Sec62 and Sec 63 J. Biol. Chem. 275 19 14550 7. doi: 10.1074 jbc.275
  • and other complexes, including the SEC62 SEC 63 integral membrane protein complex. In this mode of translocation, Sec 63 helps BiP hydrolyze ATP, which then
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