ⓘ SIGIRR

                                     

ⓘ SIGIRR

Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene.

It is observed for the modulation of immune responses, intestinal epithelial homeostasis and tumorigenesis.

                                     
  • Moreover, IL - 37 binds to single immunoglobulin IL - 1 receptor related protein SIGIRR also known as IL - 1R8 or TIR8, which forms a complex with IL - 18Rα and induces
  • IL18R1 IL18RAP IL1R1 IL1RAP IL1RAPL1 IL1RAPL2 IL1RL1 IL1RL2 MYD88 SIGIRR TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 Bonnert TP
  • IKBKG, IRAK1, IRAK2, MAP3K7IP1, MAP3K7IP2, MAP3K7 PPP4C, RANK, SDCBP, SIGIRR Sequestosome 1, TAX1BP1, TNFAIP3, TNFRSF13B, UBE2N, and Ubiquitin C. Model
  • Dinarello CA, Nold MF 2015 IL - 37 requires the receptors IL - 18Rα and IL - 1R8 SIGIRR to carry out its multifaceted anti - inflammatory program upon innate signal