ⓘ AZIN1

                                     

ⓘ AZIN1

Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene.

SLM the ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in the biosynthesis of polyamines. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding and inhibiting ornithine decarboxylase. The protein encoded by this gene is very similar to SLM. It binds to ODC antizyme and stabilizes the UNP, thus inhibiting antizyme-mediated degradation of ODS. Two alternative spliced transcript variants have been found for this gene.

                                     
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