ⓘ Mitoferrin-1

                                     

ⓘ Mitoferrin-1

Mitoferrin-1 is a 38 kDa protein that is encoded by the SLC25A37 gene in humans. It is a member of the Mitochondrial carrier Superfamily, however, its metal cargo makes it distinct from other members of this family. Mfrn1 plays a key role in mitochondrial iron homeostasis as an iron transporter, importing ferrous iron from the intermembrane space of the mitochondria to the mitochondrial matrix for the biosynthesis of heme groups and Fe-S clusters. This process is tightly regulated, given the redox potential of Mitoferrins iron cargo. Mfrn1 is paralogous to Mitoferrin-2, a 39 kDa protein encoded by the SLC25A28 gene in humans. Mfrn1 is highly expressed in differentiating erythroid cells and in other tissues at low levels, while Mfrn2 is expressed ubiquitously in non-erythroid tissues.

                                     
  • 5 - aminolevulinate synthase, ABCB10, ABCB7, succinyl - CoA synthetase, and mitoferrin - 1 Multiple studies have suggested the existence of an oligomeric complex
  • restore hemoglobinization in zebrafish deficient in Ferroportin, DMT 1 and Mitoferrin respectively. This study represents the first example of the molecular
  • oxygen species. Iron from this pool can be taken up by mitochondria via mitoferrin to synthesize Fe - S clusters and heme groups. Iron can be stored in ferritin