ⓘ SERPINI2

                                     

ⓘ SERPINI2

The protein encoded by this gene is a member of the serine protease inhibitor serpin superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.

                                     
  • Neuroserpin is a protein that in humans is encoded by the SERPINI 1 gene. It is associated with Familial encephalopathy with neuroserpin inclusion bodies
  • Marra, Cristiano Masitto 2017 - 2018 Cristian Serpini 2018 - Eccellenza: 1 2018 - 19 girone A Promozione: 2 1990 - 91 girone C 2009 - 10 girone B Supercoppa
  • Schwartzberg PL, Pavan WJ September 2005 Acinar cell apoptosis in Serpini2 - deficient mice models pancreatic insufficiency PLoS Genetics. 1 3
  • SERPINI 1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner BMC Molecular Biology. 8: 2
  • activator has been shown to interact with: Fibrinogen alpha chain LRP1 SERPINI 1 tPA and plasmin are the key enzymes of the fibrinolytic pathway in which
  • familial, with neuroserpin inclusion bodies 604218 SERPINI 1 Encephalopathy, neonatal severe 300673 MECP 2 Endocrine - cerebroosteodysplasia 612651 ICK Endometrial