ⓘ DUSP13

                                     

ⓘ DUSP13

Members of the protein tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases DSPs acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined.

                                     
  • specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP 3 gene. The protein encoded by this gene is a member of the dual specificity
  • phosphatase 7 is an enzyme that in humans is encoded by the DUSP 7 gene. Dual - specificity phosphatases DUSPs constitute a large heterogeneous subgroup of the type
  • protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP 22 gene. DUSP 22 has been shown to interact with MAPK1 and MAPK8. GRCh38: Ensembl
  • specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP 5 gene. The protein encoded by this gene is a member of the dual specificity
  • specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP 4 gene. The protein encoded by this gene is a member of the dual specificity
  • specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP 2 gene. The protein encoded by this gene is a member of the dual specificity
  • phosphatase 1 is an enzyme that in humans is encoded by the DUSP 1 gene. The expression of DUSP 1 gene is induced in human skin fibroblasts by oxidative heat
  • specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP 16 gene. The activation of mitogen - activated protein kinase MAPK cascades
  • SSH3 DUSP 1, DUSP 2, DUSP 3, DUSP 4, DUSP 5, DUSP 6, DUSP 7, DUSP 8, DUSP 9 DUSP 10, DUSP 11, DUSP 12, DUSP13 DUSP 14, DUSP 15, DUSP 16, DUSP 18, DUSP 19 DUSP 21, DUSP 22
  • Dual - specificity phosphatase DUSP DSP is a form of phosphatase that can act upon tyrosine or serine threonine residues. There are several families of
  • specificity phosphatase 27, atypical is a protein that in humans is encoded by the DUSP 27 gene. GRCh38: Ensembl release 89: ENSG00000198842 - Ensembl, May 2017 GRCm38:
  • present in the DUSP domain of USP15 and that some protein interactions with DUSP containing USPs do not occur without these domains. The DUSP domain displays