ⓘ MAFA (gene)

                                     

ⓘ MAFA (gene)

An in vivo study on mice proved MafA binds to the promoter in an insulin gene to regulate insulin transcription in response to serum glucose levels. MafA is a β cell-specific activator, which differentiates it from other transcription factors involved with insulin gene expression. It helps regulate the β cells involved with insulin secretion primarily by maintaining β cell metabolism. The amount of MafA in the β cells is regulated by levels of glucose and oxidative stress.

                                     
  • glycoprotein MafA a type of MAF gene also known as RIPE3b1, which promotes pancreatic development, as well as insulin gene transcription MAFA gene V - maf
  • Stein R March 2005 The islet beta cell - enriched MafA activator is a key regulator of insulin gene transcription The Journal of Biological Chemistry
  • S, Arney KL, Cook GP November 1998 MAFA - L, an ITIM - containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK
  • humans is encoded by the MAF gene One type, MafA also known as RIPE3b1, promotes pancreatic development, as well as insulin gene transcription. MAF has been
  • symptoms, has a highly divergent Pdx1 gene sequence compared with other mammals. Pdx1 has been shown to interact with MAFA GRCh38: Ensembl release 89: ENSG00000139515
  • Y, et al. 2008 Foxa2 and MafA regulate islet - specific glucose - 6 - phosphatase catalytic subunit - related protein gene expression J. Mol. Endocrinol
  • CREB3L3 CREB3L4 CREB5 CREBL1 CREM E4BP4 FOSL1 FOSL2 JUN JUNB JUND MAFA MAFB NFE2 NFE2L2 NFE2L3 SNFT XBP1 Ellenberger T 1994 Getting a
  • Cao H, Bai X, Liu C, Yan Q, et al. January 2020 Kindlin - 2 modulates MafA and β - catenin expression to regulate β - cell function and mass in mice Nature
  • Statistics download files www.genenames.org. HUGO Gene Nomenclature Committee. 27 January 2020. Retrieved 27 January 2020.