ⓘ TRIB2

                                     

ⓘ TRIB2

Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the TRIB2 gene. TRIB2 is a pseudokinase member of the class of signaling/scaffold proteins, possessing little vestigial catalytic output in vitro. It is known to signal to canonical MAPK pathways and to regulate the ubiquitination of substrates with important functions in the immune system. It has also been associated with various diseases, especially in vertebrate leukaemia models. Like TRIB1 and TRIB3, TRIB2 has recently been considered as a potential allosteric drug target, and is a putative regulator of cancer-associated signalling and survival through AKT pSer473 modulation

                                     
  • substrates such as C EBPalpha and a key regulatory C - tail region. Like TRIB2 and TRIB 3, TRIB 1 has recently been considered as a potential allosteric drug target
  • TRIB 3 has recently been associated with neuronal signalling, and like TRIB 1 and TRIB2 could be considered as a potential allosteric drug target TRIB 3
  • any enzymatic activity. Some are related to CAMK: Tribbles subfamily TRIB 1 TRIB2 TRIB 3 Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman
  • released at least two known 45 rpm singles, Over the Edge T K 917010 - TRIB2 and Miss World Over the Edge T K 947081 According to AllMusic
  • Tribeca Trib is an award - winning monthly newspaper and website covering Lower Manhattan. Named after the community where it started, the Tribeca Trib covers
  • The Pittsburgh Tribune - Review, also known as the Trib is the second largest daily newspaper serving metropolitan Pittsburgh, Pennsylvania, in the United
  • 40 26 13 N 80 0 39 W 40.43694 N 80.01083 W 40.43694 - 80.01083 The Trib Total Media Amphitheatre was an outdoor music pavilion at Station Square
  • Capone Mobster, Chi. Trib Feb. 9, 1940, at 15. Tells of Playing Bootlegger to Nab Fix Figures, Chi. Trib Feb. 15, 1940, at 2 Free Bootlegger Says
  • Southam Inc at the time of its demise. It was frequently referred to as The Trib The Winnipeg Tribune began publishing on January 28, 1890 as a city newspaper
  • TRIB1  TRIB2 TRIB 3  TRIO  TSSK1B  TSSK 2 TSSK3  TSSK4  TSSK6  TTBK1  TTBK 2 TTK  TTN  TXK  TYK 2 TYRO3  UHMK1  ULK1  ULK 2 ULK3 
  • CHEK 2 Checkpoint kinase 2 is a tumor suppressor gene that encodes the protein CHK 2 a serine - threonine kinase. CHK 2 is involved in DNA repair, cell
  • tributaries. Trib 27590 to Dark Run is the first unnamed tributary to enter the stream. It is followed closely by Trib 27589 to Dark Run Trib 27588 to
  • moved west to Denver, becoming the Colorado Mammoth. Dave Mackall. Pro lacrosse league stages Pittsburgh game TRIB live. Retrieved August 2 2019.