ⓘ TSPAN32

                                     

ⓘ TSPAN32

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes, however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 TSSC4, escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function.