ⓘ UBXD5

                                     

ⓘ UBXD5

This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3 coding sequence of this gene contains a polymorphic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene.

                                     
  • Peterhoff C, Nixon RA, Monteiro MJ Sep 2006 Characterization of erasin UBXD 2 a new ER protein that promotes ER - associated protein degradation J Cell
  • Kawate Y, Matsui T, Miyake H, Yuasa K, Tani K, Tagaya M, Tsuji A May 2009 UBXD 1 is a VCP - interacting protein that is involved in ER - associated degradation
  • susceptibility gene BRCA1. Rnd2 has been shown to interact with: ARHGAP 5 RACGAP1, and UBXD5 GRCh38: Ensembl release 89: ENSG00000108830 - Ensembl, May 2017
  • 2012 Derlin - 1 and UBXD 8 are engaged in dislocation and degradation of lipidated ApoB - 100 at lipid droplets Mol. Biol. Cell. 23 5 800 10. doi: 10.1091 mbc
  • domain - containing protein 2 TSGA10 encoding protein Testis specific 10 TTN: titin UBXD 2: UBX domain - containing protein 4 UXS1: UDP - glucuronic acid decarboxylase
  • which chooses its substrates very selectively, and MAPK1, PRMT 5 CDK1, CDK4, β - catenin, and UBXD 8 have been identified as ubiquitination targets of this protein
  • Graumann, J., Smith, G.T., Kolawa, N.J., Fang, R., and Deshaies, R.J. 2008 UBXD 7 binds multiple ubiquitin ligases and implicates p97 in HIF1a turnover. Cell
  • Caenorhabditis elegans by comparative proteomics Genome Res. 10 5 703 13. doi: 10.1101 gr.10. 5 703. PMC 310876. PMID 10810093. Buchberger A, Howard MJ, Proctor
  • Syntaxin 5 is a common component of the NSF - and p97 - mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro Cell. 92 5 603 10