ⓘ TMEM59

                                     

ⓘ TMEM59

Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene.

TMEM59 is a membrane bound protein that is localized in the Golgi apparatus. The exact functions of TMEM59 is not known, but it is shown that the expression of TMEM59 inhibits protein glycosylation Golgi amyloid precursor protein app and the app blocks the degradation of α - and β-amyloid protein precursor secretases and thus prevents the formation of beta amyloid peptide, which forms amyloid plaques in Alzheimers disease.Additionally, TMEM59 was shown to potentiate the WNT siganling by promoting the formation of receptor signalosomes VNT. The interaction between TMEM59 transmembrane receptor Frizzled and the WNT has been found on the disc receptor multimerization, which leads to improved potency and efficiency of this signaling pathway.

                                     
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