ⓘ MASTL

                                     

ⓘ MASTL

MASTL is an official symbol provided by HGNC for human gene whose official name is micro tubule associated serine/threonine kinase like. This gene is 32.1 kbps long. This gene is also known as GW, GWL, THC2, MAST-L, GREATWALL. This is present in mainly mammalian cells like human, house mouse, cattle, monkey, etc. It is in the 10th chromosome of the mammalian nucleus. Recent studies have been carried on zebrafish and frogs. This gene encodes for the protein micro tubule associated serine/threonine kinase and its sub-classes.

Micro-tubules associated serine / threonine protein kinase is an enzyme of mammals, which was first discovered in Drosophila as a critical kinase of the great wall for proper chromosome condensation and mitotic progression. The EC number for this enzyme 2.7.11.12. This enzyme is active during mitotic division and mainly localized in the nucleus during interphase. They are scattered in the cytoplasm with the degradation of the nuclear envelope during mitosis. In MASTL depleted cells are delayed by RNA interference in G2 phase and reduction of condensation of chromosomes. Cells RNA, which go through mitosis, can not separate their sister chromatids in anaphase. It causes chromatin trapped in the cleavage furrow and the form 4N G1 cells due to a cytokinesis failure. This enzyme enhances cyclin B1-Cdk1-dependent events of mitosis phosphorylation during mitosis.

This enzyme is also important for the record, metaphase, inhibiting protein phosphatase 2A, which, in turn, leads to a high level of Cdk1 substrate phosphorylation. He also ensures the timely activation of APC / C during meiosis I and Cdk1 reactivation in meiosis II.

Mutations in the gene

Missense mutation in the MASTL gene can cause an autosomal dominant inherited thrombocytopenia. Mutation in connection with a change in the amino acid glutamic acid 167 to aspartic acid. The overall mild phenotype of the patient thrombocytopenia is a decrease in the average plate counts of 60.000 platelets per ml of blood.

Used in therapeutic area

MASTL enzyme is also used for therapeutic applications such as cancer progression and tumor recurrence after cancer treatment and this enzyme may be of higher value in the therapeutic market.

                                     
  • gravitational wave observation GW, an alternative signifier for the human gene MASTL Games Workshop, a publicly traded company that makes war games Gateway disambiguation
  • strand of human chromosome ten, located next to the 5 end of ANKRD26 is MASTL microtubule associated serine threonine kinase - like. This particular gene
  • MAPKAPK5  MARK1  MARK2  MARK3  MARK4  MAST1  MAST2  MAST3  MAST4  MASTL MATK  MELK  MERTK  MET  MINK1  MKNK1  MKNK2  MLKL  MOK  MOS 
  • promoting factor CDK cyclin A cyclin B cyclin D cyclin E Wee cell cycle Mastl GRCh38: Ensembl release 89: ENSG00000170312 - Ensembl, May 2017 GRCm38:
  • HGNC: 19035 Q6P0Q8 9300 MAST3 HGNC: 19036 O60307 9301 MAST4 HGNC: 19037 O15021 9302 MASTL HGNC: 19042 Q96GX5 9303 MAT1A HGNC: 6903 Q00266 9304 MAT2A HGNC: 6904 P31153