ⓘ PCDHB14

                                     

ⓘ PCDHB14

Protocadherin beta-14 is a protein that in humans is encoded by the PCDHB14 gene.

This gene is a member of the protocadherin beta gene cluster one of three related gene clusters tandemly linked on chromosome 5. The gene clusters demonstrate an unusual genomic organization similar to B-cell and T-cell receptor gene clusters.

The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that differs from others in the cadherin superfamily. The extracellular Domains interact in a homophilic manner to specify differential cell-cell connections.

Unlike alpha and gamma clusters, the transcripts of these genes consist of only one large exon, not sharing common 3 exons as expected. These neural cadherin-cell adhesion proteins are integral proteins of the plasma membrane. Their specific functions are unknown but they are likely to play an important role in the establishment and operation of specific extracellular neural connections.

                                     
  • PCDHAC2 PCDHB 1 PCDHB 2 PCDHB 3 PCDHB 4 PCDHB 5 PCDHB 6 PCDHB 7 PCDHB 8 PCDHB 9 PCDHB 10 PCDHB 11 PCDHB 12 PCDHB 13 PCDHB14 PCDHB 15 PCDHB 16 PCDHB 17 PCDHB 18 PCDHGA1
  • PCDHAC2 PCDHB 1 PCDHB 2 PCDHB 3 PCDHB 4 PCDHB 5 PCDHB 6 PCDHB 7 PCDHB 8 PCDHB 9 PCDHB 10 PCDHB 11 PCDHB 12 PCDHB 13 PCDHB14 PCDHB 15 PCDHB 16 PCDHB 17 PCDHB 18 PCDHGA1
  • Protocadherin beta - 9 is a protein that in humans is encoded by the PCDHB 9 gene. This gene is a member of the protocadherin beta gene cluster, one of three
  • Protocadherin beta - 5 is a protein that in humans is encoded by the PCDHB 5 gene. This gene is a member of the protocadherin beta gene cluster, one of three
  • Protocadherin beta - 2 is a protein that in humans is encoded by the PCDHB 2 gene. This gene is a member of the protocadherin beta gene cluster, one of three
  • Protocadherin beta - 12 is a protein that in humans is encoded by the PCDHB 12 gene. This gene is a member of the protocadherin beta gene cluster, one of
  • Protocadherin beta - 11 is a protein that in humans is encoded by the PCDHB 11 gene. This gene is a member of the protocadherin beta gene cluster, one of
  • Protocadherin beta - 7 is a protein that in humans is encoded by the PCDHB 7 gene. This gene is a member of the protocadherin beta gene cluster, one of three
  • Protocadherin beta - 3 is a protein that in humans is encoded by the PCDHB 3 gene. This gene is a member of the protocadherin beta gene cluster, one of three
  • Protocadherin beta - 15 is a protein that in humans is encoded by the PCDHB 15 gene. This gene is a member of the protocadherin beta gene cluster, one of