ⓘ TREM2

                                     

ⓘ TREM2

Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors e.g., FPR1, Fc receptors, CD14 and Toll-like receptors e.g., TLR4, and cytokine receptors e.g., IFNGR1. Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Immunoglobulin Ig superfamily, such as TREM2, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating e.g., KIR2DS1 or inhibitory functions e.g., KIR2DL1.

When stimulated, engaged in DAP12 TREM2, as a result of two tyrosines in immunoreceptor tyrosine activation motif ITAM become fosfauriliruetsa. The family of SYK spleen tyrosine kinase then docks into these sites of phosphorylation and activate phosphatidylinositol-3-kinase PI3K cascade, which promotes several cell functions such as cell survival, phagocytosis, production of Pro-inflammatory cytokines, and cytoskeletal rearrangements through various transcription factors, including AP1, NF-KB, and NFAT.

                                     
  • TREM 1, Triggering receptor expressed on myeloid cells 1, a human gene TREM2 Triggering receptor expressed on myeloid cells 2 a human gene Trem Desportivo
  • receptor expressed on myeloid cells 2 TREM2 gene. TYROBP is located on the long arm of chromosome 19 19q13.12 and TREM2 is located on short arm of chromosome
  • Trans Trem is a guitar vibrato system developed by Steinberger in 1984. Its main feature is to maintain the pitch of each string at the proper tuning interval
  • receptors TREM 1 MIM 605085 and TREM2 MIM 605086 but it has distinct structural and functional properties. TREML1 enhances calcium signaling in an SHP 2 PTPN11
  • expressed on myeloid cells 1 is a protein that in humans is encoded by the TREM 1 gene. Monocyte macrophage - and neutrophil - mediated inflammatory responses
  • Trem Desportivo Clube, usually known as Trem Desportivo, or simply as Trem is a Brazilian football club from Macapa, Amapa state. On January 1, 1947
  • O Trem da Morte also known as A Metralha no Sertão Paulista and Coluna da Morte is a 1924 Brazilian film directed by Jose del Picchia, and starring Olga
  • TRBV5 - 4 TRBV7 - 2 TRDV 2 TREM 1 TREM2 TREML1 TREML 2 TREML4 TRGV3 TRGV5 TRGV7 TRGV9 VCAM1 VCAN VPREB1 VPREB3 VSIG1 VSIG 2 VSIG4 VSIG9 VSIG10
  • Atletico Clube Santos Futebol Clube Sociedade Esportiva e Recreativa São Jose Trem Desportivo Clube Ypiranga Clube Others Clube Atletico Aliança Esporte Clube
  • The Rio São Paulo High - Speed Rail Portuguese: Trem de Alta Velocidade Rio - São Paulo Abbreviation: TAV RJ - SP is a planned high - speed rail project to
  • Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR, Lessnick SL May 2006 Expression profiling of EWS FLI identifies NKX 2 2 as a critical target