ⓘ DKK2

                                     

ⓘ DKK2

Dickkopf-related protein 2 is a protein that in humans is encoded by the DKK2 gene.

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development, in cooperation with the Wnt signaling pathway.

It can act as agonists or antagonists of the signaling pathway Wnt / beta-Catenin, depending on the cellular context and the presence of co-factor Kremen 2. The activity of this protein is also modulated by binding to the WNT co-receptor LDL-receptor related protein 6 LRP6.