ⓘ DUSP5

                                     

ⓘ DUSP5

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein MAP kinase superfamily, which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1/2, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.

                                     
  • specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP 3 gene. The protein encoded by this gene is a member of the dual specificity
  • protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP 22 gene. DUSP 22 has been shown to interact with MAPK1 and MAPK8. GRCh38: Ensembl
  • These include DUSP 1, DUSP 2, DUSP 4 and DUSP5 that belong to subgroup 1. DUSP 6, DUSP 7, DUSP 9 and DUSP 10 belong to subgroup 2. DUSP 8 and DUSP 16 belong to subgroup
  • specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP 10 gene. Dual specificity protein phosphatases inactivate their target kinases
  • Dual specificity phosphatase 6 DUSP 6 is an enzyme that in humans is encoded by the DUSP 6 gene. The protein encoded by this gene is a member of the dual
  • Dual specificity protein phosphatase 18 is an enzyme that is encoded by the DUSP 18 gene in humans. GRCh38: Ensembl release 89: ENSG00000167065 - Ensembl
  • C - terminal hydrolases. CDC25A CDC25B CDC25C DUSP DUSP 1 DUSP 10 DUSP 16 DUSP 2 DUSP 4 DUSP5 DUSP 6 DUSP 7 KAT MKP7 MOCS3 MPST TBCK TSGA14 TST
  • protein phosphatase 19 is an enzyme that in humans is encoded by the DUSP 19 gene. DUSP 19 has been shown to interact with ASK1 and MAP2K7. GRCh38: Ensembl
  • phosphatase 1 is an enzyme that in humans is encoded by the DUSP 1 gene. The expression of DUSP 1 gene is induced in human skin fibroblasts by oxidative heat