ⓘ GGPS1

                                     

ⓘ GGPS1

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate GGPP synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

As well as its homolog farnesyl diphosphate synthase, is inhibited GGPS1 bisphosphonate compounds.

                                     
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