ⓘ MTDH

                                     

ⓘ MTDH

MTDH AEG-1 is involved in HIF-1alpha mediated angiogenesis. MTDH also interacts with SND1 and involved in RNA-induced silencing complex RISC and plays very important role in RISC and miRNA functions. MTDH has been shown to interact with spliceosome proteins in the cell nucleus and regulate the process of alternative splicing.

MTDH induces an oncogene called late SV40 factor, LSF / TFCP2, which is involved in thymidylate synthase TS induction and synthesis of DNA biosynthesis. Late SV40 factor, LSF / TFCP2 enhances angiogenesis through transcriptional regulation of matrix metalloproteinase-9 MMP9.

                                     
  • MTDH and EZH2. It further induces apoptosis, inhibition of colony formation and tumorigenesis of breast cancer cells in vivo. A decrease in MTDH and
  • facilitate the RLC. Recently identified members of RISC are SND1 and MTDH SND1 and MTDH are oncogenes and regulate various gene expression. Ago, Argonaute
  • increased aggresivness, including histological transformation. c - Myc induces MTDH AEG - 1 gene expression and in turn itself requires AEG - 1 oncogene for its
  • HGNC: 17587 Q9Y6C9 9981 MTCL1 HGNC: 29121 Q9Y4B5 9982 MTCP1 HGNC: 7423 P56278 9983 MTDH HGNC: 29608 Q86UE4 9984 MTERF1 HGNC: 21463 Q99551 9985 MTERF2 HGNC: 30779 Q49AM1