ⓘ LOXL4

                                     

ⓘ LOXL4

Lysyl oxidase homolog 4 is an enzyme that in humans is encoded by the LOXL4 gene.

This gene encodes a family member of the gene lysyl oxidase. The prototype member of the family is essential for biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase, which catalyzes the first step in the formation of cross-linking in collagens and elastin. A very conservative amino acid sequence at the C-end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. N-Terminus is poorly conserved and may impart additional roles in the regulation of development, aging, tumor suppression, cell growth control, and chemotaxis to each member of the family.

                                     
  • such as liver fibrosis. LOXL1 LOXL 3 LOXL4 Overview of all the structural information available in the PDB for UniProt: Q9Y 4 K0 Lysyl oxidase homolog 2
  • happens in the eye, exfoliation glaucoma results. LOXL 1 has been shown to interact with FBLN5. LOXL 2 LOXL 3 LOXL4 GRCh38: Ensembl release 89: ENSG00000129038
  • arthropathy joint pathology and vitreoretinopathy pathology of the eye LOXL 1 LOXL 2 LOXL4 GRCh38: Ensembl release 89: ENSG00000115318 - Ensembl, May 2017 GRCm38:
  • matrix, including neurodegenerative and cardiovascular diseases. LOXL 1 LOXL 2 LOXL 3 LOXL4 Menkes disease Occipital horn syndrome GRCh38: Ensembl release
  • has associated PEX with polymorphisms in gene LOXL 1. A report suggested that a specific gene named LOXL 1 which was a member of the family of enzymes which
  • vascular development and remodeling. FBLN5 has been shown to interact with LOXL 1 and apolipoprotein a FBLN5 mutations have been described in patients with
  • effects. Simtuzumab is a monoclonal antibody against the pro - fibrotic enzyme LOXL 2 that is being developed as a possible therapy for PSC. Chris Klug professional