ⓘ PCGF6

                                     

ⓘ PCGF6

Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene.

The protein encoded by this gene contains a motif of the ring finger, which has a direct relationship to the polycomb group PCG proteins RNF110 / Mel-18 and BMI1. PCG proteins are known to form protein complexes and function as a repressor of transcription. This protein has been shown to interact with some PCG proteins and act as transcriptional repressor. The activity of this protein is regulated dependent on the cell cycle phosphorylation. Alternative spliced transcripts variants encoding different isoforms have been identified.

                                     
  • MKRN1, MKRN2, MKRN3, MKRN4, MNAT1, MYLIP, NFX1, NFX2, PCGF1, PCGF 2, PCGF 3, PCGF 4, PCGF 5, PCGF6 PDZRN3, PDZRN4, PEX10, PHRF1, PJA1, PJA2, PML, PML - RAR, PXMP3
  • group RING finger protein 1 is a protein that in humans is encoded by the PCGF 1 gene. GRCh38: Ensembl release 89: ENSG00000115289 - Ensembl, May 2017 GRCm38:
  • and STARD4 and three genes associated with a favorable outcome CAMSAP1, PCGF6 and SH3RF3 Thus it appears that FASTKD1 may also play a role in ALL. GRCh38:
  • non - canonical polycomb repressive complex 1.1 ncPRC1.1 containing BCOR, PCGF 1, RING1 2 and RYBP that mono - ubiquitylates histone H2A on K119. This gene
  • complex protein BMI - 1 also known as polycomb group RING finger protein 4 PCGF 4 or RING finger protein 51 RNF51 is a protein that in humans is encoded
  • Nakayama M, Schermelleh L, Nesterova TB, Koseki H, Brockdorff N June 2017 PCGF 3 5 - PRC1 initiates Polycomb recruitment in X chromosome inactivation Science
  • Proteins and Cancer PRC1 PRC2 PHC1 PHC2 Heterochromatin protein 1 Cbx BMI1 PCGF 2 Polycomb group RING finger protein 2 ortolog Bmi1 RYBP RING1 SUV39H1 histone - lysine
  • Bonasio R, Strino F, Sawai A, Parisi F, Kluger Y, Reinberg D Feb 2012 PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family
  • On the centromeric side, it is followed by the C31, LBX2, LBX2 - AS1, and PCGF 1 genes. In Homo sapiens, the CCDC142 gene encodes for two alternatively spliced