ⓘ PCDHB13

                                     

ⓘ PCDHB13

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3 exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

                                     
  • PCDHA 13 PCDHAC1 PCDHAC2 PCDHB 1 PCDHB 2 PCDHB 3 PCDHB 4 PCDHB 5 PCDHB 6 PCDHB 7 PCDHB 8 PCDHB 9 PCDHB 10 PCDHB 11 PCDHB 12 PCDHB13 PCDHB 14 PCDHB 15 PCDHB 16 PCDHB 17 PCDHB18
  • PCDHA 13 PCDHAC1 PCDHAC2 PCDHB 1 PCDHB 2 PCDHB 3 PCDHB 4 PCDHB 5 PCDHB 6 PCDHB 7 PCDHB 8 PCDHB 9 PCDHB 10 PCDHB 11 PCDHB 12 PCDHB13 PCDHB 14 PCDHB 15 PCDHB 16 PCDHB 17 PCDHB18
  • Protocadherin beta - 11 is a protein that in humans is encoded by the PCDHB 11 gene. This gene is a member of the protocadherin beta gene cluster, one of
  • Protocadherin beta - 14 is a protein that in humans is encoded by the PCDHB 14 gene. This gene is a member of the protocadherin beta gene cluster, one of